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Oxidized LDL
Pathway / Lipid retention & oxidation

Oxidized LDL

lipoprotein

Oxidized LDL drives plaque formation, inflammation, and endothelial dysfunction in atherothrombotic disease.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleAnchor molecule; oxidative modification of retained lipoprotein initiates atherogenesis.
Also acts inVascular inflammation, Endothelial activation/erosion
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
67
A — assay feasibility
82
E — evidence strength
86
T1DI (composite)
35
Specificity differential (R−C)0
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 16 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma (EDTA to limit ex-vivo oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Sandwich ELISA
Reagent / substrate
mAb 4E6 (or anti-oxLDL) capture + anti-apoB detection
Platform
ELISA plate
Turnaround · availability
Research/send-out · Research/CE

Literature evidence(60)

Showing 40 of 60 linked references.

Clinical trials(2)