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P-selectin+ microparticles
Pathway / Platelet adhesion & activation

P-selectin+ microparticles

complex

P-selectin+ microparticles are released during platelet activation and mediate leukocyte adhesion at sites of arterial injury.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleP-selectin+ microparticles mark platelet activation and platelet–leukocyte interaction; predict cardiovascular events.
Also acts inVascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
75
C — non-Type-I
53
A — assay feasibility
58
E — evidence strength
26
T1DI (composite)
9
Specificity differential (R−C)+22.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized

Literature evidence(1)