Palmitoleic acid
metaboliteMonounsaturated fatty acid elevated in ACS, reflecting ischemia-associated acylcarnitine dysmetabolism.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleMonounsaturated fatty acid and acylcarnitine marker; ischemia-associated metabolite in ACS.
Also acts inSystemic / off-pathway
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I20
C — confounder / Type-II38
A — assay feasibility42
E — evidence strength15
T1DI (composite)3
Specificity differential (R−C)-18.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(3)
- Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction.Biomolecules · 2024 · PMID 38785939 · doi
- GC-MS validation and analysis of targeted plasma metabolites related to carbonyl stress in type 2 diabetes mellitus patients with and without acute coronary syndrome.Biomedical chromatography : BMC · 2024 · PMID 38966927 · doi
- Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.PloS one · 2019 · PMID 30707740 · doi