Pathway / Myocardial injury (shared endpoint)

PELATON

rna

PELATON is a circulating RNA whose expression is dysregulated in acute coronary syndromes and may reflect either myocardial injury or vascular inflammation.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencelow

RationaleCirculating RNA biomarker associated with ACS incidence and prognosis; mechanism not fully established.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood (transcript)

Collection tube

PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)

Method / principle

RT-qPCR (TaqMan) or small-RNA sequencing

Reagent / substrate

Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)

Platform

qPCR instrument / NGS

Turnaround · availability

Research / send-out · Research (few LDTs)

Literature evidence(1)

High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.
Scientific reports · 2022 · PMID 35577857 · doi