Phosphatidylethanolamines
lipidPhosphatidylethanolamine enrichment in atherosclerotic lipoproteins reflects atherogenic lipid remodeling.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleLipoprotein and plaque lipid species; elevated in proatherogenic lipidome.
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I65
C — confounder / Type-II73
A — assay feasibility40
E — evidence strength29
T1DI (composite)5
Specificity differential (R−C)-8.6
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(2)
- Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study.eLife · 2022 · PMID 35535496 · doi
- Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.Environment international · 2022 · PMID 36495677 · doi