Phosphatidylinositol
lipidPhosphatidylinositol is a structural lipoprotein lipid altered by oxidative stress; reduced levels in MI-prone and vascular disease states mark lipid peroxidation and dysfunction.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleLipoprotein lipid component; oxidative degradation in atherosclerosis and MI-prone states.
Also acts inMyocardial injury
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(6)
- Bioactive lipids in plasma and atherogenic apoB-containing lipoproteins: Effects of statins and PCSK9 inhibitors and relevance to residual cardiovascular risk.Pharmacology & therapeutics · 2026 · PMID 42162924 · doi
- Lipidomic Signature of Abdominal Aortic Aneurysm and Peripheral Artery Disease.Journal of proteome research · 2025 · PMID 40910695 · doi
- Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model.Journal of lipid research · 2024 · PMID 38246237 · doi
- Lipidomics Approach in High-Fat-Diet-Induced Atherosclerosis Dyslipidemia Hamsters: Alleviation Using Ether-Phospholipids in Sea Urchin.Journal of agricultural and food chemistry · 2021 · PMID 33961420 · doi
- Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits.Journal of bioscience and bioengineering · 2015 · PMID 26162515 · doi
- Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction.PloS one · 2015 · PMID 26258408 · doi