Phosphatidylinositol 16:1/18:0
lipidPhosphatidylinositol species composition predicts lipid-lowering therapeutic efficacy.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleLDL lipidomic marker predicting statin response and lipid remodeling.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(1)
- Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia.Chemistry and physics of lipids · 2023 · PMID 37827478 · doi