Pro-substance P
peptidePro-substance P amplifies vascular inflammation and platelet activation, increasing post-MI adverse-event risk.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationalePro-inflammatory neuropeptide surrogate; promotes plaque inflammation and MACE post-AMI.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade
Literature evidence(1)
- Pro-substance p for evaluation of risk in acute myocardial infarction.Journal of the American College of Cardiology · 2014 · PMID 25323258 · doi