Proneurotensin

peptide

Proneurotensin is a novel CVD predictor in women, acting through neuroendocrine pathways independent of atherothrombotic mechanisms.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencelow

RationaleNovel CVD biomarker in women; mechanism unclear; likely neurohormonal/systemic rather than atherothrombotic cascade.

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)

Collection tube

K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)

Method / principle

Competitive/sandwich immunoassay or LC-MS/MS

Reagent / substrate

Anti-peptide antibody; or isotope-labeled internal standard (MS)

Platform

Immunoassay / LC-MS/MS

Turnaround · availability

Send-out / research · Research-grade