Prostacyclin
metaboliteProstacyclin maintains endothelial function and opposes platelet activation, protecting against thrombosis in Type 1 MI.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleEndothelial function regulator; platelet aggregation inhibitor; vasodilation mediator.
Also acts inPlatelet activation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(6)
- Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021 · PMID 33450492 · doi
- Endothelial progenitor cells bind and inhibit platelet function and thrombus formation.Circulation · 2009 · PMID 19917882 · doi
- Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection.Seminars in thrombosis and hemostasis · 2005 · PMID 15852226 · doi
- Enhanced platelet/endothelial activation in depressed patients with acute coronary syndromes: evidence from recent clinical trials.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2003 · PMID 12960610 · doi
- Atherosclerosis-associated endothelial dysfunction.Zeitschrift fur Kardiologie · 2000 · PMID 11151799 · doi
- Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes.Clinical chemistry · 1998 · PMID 9702994