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Prothrombin Fragment 1+2
Pathway / Coagulation & thrombus formation

Prothrombin Fragment 1+2

protein

Prothrombin fragment 1+2 is released during tissue-factor-triggered coagulation, indicating thrombin generation during coronary thrombosis.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleF1+2 is a direct product of Factor Xa activation of prothrombin; anchoring marker of thrombin generation.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
91
C — confounder / Type-II
72
A — assay feasibility
68
E — evidence strength
35
T1DI (composite)
14
Specificity differential (R−C)+19.2
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(24)