Remnant lipoprotein
lipoproteinRemnant lipoproteins are retained and oxidized in the arterial intima, initiating atherosclerotic plaque formation and Type 1 MI risk.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleAtherogenic lipoprotein subclass; oxidized form drives plaque initiation and lipid retention.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Specialized reference method
Specimen
Serum or plasma (EDTA)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
NMR lipoprotein particle analysis or density-gradient ultracentrifugation
Reagent / substrate
No chemical reagent — NMR spectral deconvolution of lipid methyl signals (or ultracentrifugal separation by density)
Platform
NMR (LabCorp NMR LipoProfile) / analytical ultracentrifuge
Turnaround · availability
Send-out · Specialized reference lab
Literature evidence(3)
- Lipoproteins, Cholesterol, and Atherosclerotic Cardiovascular Disease in East Asians and Europeans.Journal of atherosclerosis and thrombosis · 2023 · PMID 37704428 · doi
- Assessment of Remnant Lipoprotein Cholesterol and Oxidized Low density Lipoprotein Associated with Low-grade Inflammation in Coronary Heart Disease Subjects of Young South Indian Population.The Journal of the Association of Physicians of India · 2022 · PMID 35702834 · doi
- The oxidative modification hypothesis of atherosclerosis: the comparison of atherogenic effects on oxidized LDL and remnant lipoproteins in plasma.Clinica chimica acta; international journal of clinical chemistry · 2006 · PMID 16448638 · doi