RNA component of mitochondrial RNA processing
rnaRMRP is a circulating non-coding RNA that discriminates acute MI subtypes and detects acute myocardial injury in coronary syndromes.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCirculating ncRNA with high discriminatory power for ACS subtypes.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood (transcript)
Collection tube
PAXgene/Tempus RNA tube · K2/K3-EDTA (lavender-top)
Method / principle
RT-qPCR (TaqMan) or small-RNA sequencing
Reagent / substrate
Target-specific primers/probe; reverse transcriptase (miRNA: stem-loop RT primer)
Platform
qPCR instrument / NGS
Turnaround · availability
Research / send-out · Research (few LDTs)
Literature evidence(1)
- Discriminatory power of a circulating multi-noncoding RNA panel in acute coronary syndrome subtypes: Towards precision detection.The international journal of biochemistry & cell biology · 2024 · PMID 38280541 · doi