Serine
metaboliteAn amino acid employed in metabolite-ratio diagnostics for acute myocardial necrosis in STEMI.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencelow
RationaleAmino acid in diagnostic biomarker ratios for ACS and myocardial injury detection.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- GC-MS validation and analysis of targeted plasma metabolites related to carbonyl stress in type 2 diabetes mellitus patients with and without acute coronary syndrome.Biomedical chromatography : BMC · 2024 · PMID 38966927 · doi
- Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction.Scientific reports · 2024 · PMID 39394398 · doi