Sphinganine
metaboliteSphinganine, a sphingoid base precursor, accumulates in response to environmental particulate matter and mediates oxidative inflammation driving atherosclerosis progression.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleSphingoid base precursor; PM-induced atherosclerosis mediator with pro-inflammatory and oxidative properties.
Also acts inLipid entry/oxidation
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(1)
- Ambient Air Pollution and Atherosclerosis: A Potential Mediating Role of Sphingolipids.Arteriosclerosis, thrombosis, and vascular biology · 2022 · PMID 35652334 · doi