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Sphingomyelin (42:3)
Pathway / Endothelial activation & erosion

Sphingomyelin (42:3)

lipid

Sphingomyelin (42:3) protects endothelial cell integrity and reduces apoptosis, opposing erosion mechanisms.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleSphingomyelin species inhibits endothelial apoptosis; protects against erosion.
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
68
C — non-Type-I
74
A — assay feasibility
40
E — evidence strength
34
T1DI (composite)
6
Specificity differential (R−C)-6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only

Literature evidence(1)