CoronaryAtlas logo
CoronaryAtlas
Terminal complement complex
Pathway / Plaque inflammation

Terminal complement complex

complex

Terminal complement complex activation marks systemic inflammatory cascade and prothrombotic state in acute MI.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleComplement activation marker; inflammatory driver in STEMI and thrombosis.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
48
C — non-Type-I
62
A — assay feasibility
58
E — evidence strength
26
T1DI (composite)
7
Specificity differential (R−C)-13.6
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized

Literature evidence(1)