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Terminal complement complex
Pathway / Plaque inflammation

Terminal complement complex

complex

Terminal complement complex activation marks systemic inflammatory cascade and prothrombotic state in acute MI.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleComplement activation marker; inflammatory driver in STEMI and thrombosis.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
48
C — confounder / Type-II
64
A — assay feasibility
58
E — evidence strength
25
T1DI (composite)
6
Specificity differential (R−C)-15.4
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized

Literature evidence(1)