Triacylglycerol
lipidTriacylglycerol-rich lipoproteins are retained in plaque and promote atherogenesis and plaque vulnerability.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleSerum biomarker in atherosclerosis; elevated in MI-prone models; core lipid in plaque retention.
Also acts inSystemic / off-pathway
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I50
C — confounder / Type-II71
A — assay feasibility40
E — evidence strength27
T1DI (composite)4
Specificity differential (R−C)-21.6
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(4)
- Longitudinal lipidomic signature of carotid atherosclerosis in American Indians: Findings from the Strong Heart Family Study.Atherosclerosis · 2023 · PMID 37722315 · doi
- Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation.Circulation · 2022 · PMID 35422138 · doi
- Lipidomics Approach in High-Fat-Diet-Induced Atherosclerosis Dyslipidemia Hamsters: Alleviation Using Ether-Phospholipids in Sea Urchin.Journal of agricultural and food chemistry · 2021 · PMID 33961420 · doi
- Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits.Journal of bioscience and bioengineering · 2015 · PMID 26162515 · doi
Clinical trials(1)
- Effects of a High-dose Concentrate of n-3 Fatty Acids or Corn Oil Introduced Early After an Acute Myocardial Infarction on Serum Triacylglycerol and High-density Lipoprotein (HDL)- CholesterolNCT01422317 · PHASE3 · COMPLETED · EPA / DHA / Alpha-Tocopherol, Corn Oil / Alpha-Tocopherol (4 mg)