Triacylglycerols
lipidElevated triacylglycerols in plaque and thrombus mark atherosclerotic burden, plaque vulnerability, and thrombotic risk.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencehigh
RationaleCarotid disease biomarker; plaque and thrombus composition; vulnerable plaque predictor.
Also acts inPlatelet activation, Coagulation / thrombus
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(6)
- Lipidomic Expression Analysis in Carotid Atherosclerotic Disease: A Systematic Review.Annals of vascular surgery · 2025 · PMID 39855383 · doi
- Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025 · PMID 40322967 · doi
- Spatial lipidomics of coronary atherosclerotic plaque development in a familial hypercholesterolemia swine model.Journal of lipid research · 2024 · PMID 38246237 · doi
- Plasma lipidome differences in patients with and without significant carotid plaque.Vascular pharmacology · 2024 · PMID 38705432 · doi
- Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.Environment international · 2022 · PMID 36495677 · doi
- Lipidomic signatures of aortic media from patients with atherosclerotic and nonatherosclerotic aneurysms.Scientific reports · 2019 · PMID 31664168 · doi