Tyrosine
metaboliteTyrosine dysmetabolism reflects systemic ischemic stress and myocardial metabolic dysfunction during acute MI.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleAmino acid AMI biomarker; ischemic stress marker not direct pathway molecule.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- Improved Risk Prediction of Acute Myocardial Infarction in Patients With Stable Coronary Artery Disease Using an Amino Acid-Assisted Model.Cardiovascular therapeutics · 2024 · PMID 39742009 · doi
- NMR plasma metabolomics study of patients overcoming acute myocardial infarction: in the first 12 h after onset of chest pain with statistical discrimination towards metabolomic biomarkers.Physiological research · 2020 · PMID 32901496 · doi