Vitamin E

metabolite

Vitamin E depletion reflects oxidative stress during LDL modification and lipid-core pathogenesis in atherosclerotic plaque.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencemedium

RationaleAntioxidant; counters lipid oxidation in subendothelial retention.

Druggability

Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresIndeterminate

R — rupture / Type-I

—

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+3.9

Confounder panel (Type-II drivers)

1sepsis / systemic inflammationn/a

2anemia / acute blood lossmag 0

3hypovolemia / dehydrationmag 0

4tachyarrhythmiamag 2

5hypoxemia / respiratory failuremag 0

6hypertensive emergencymag 0

7high-demand / peri-operative stressmag 0

Coverage: 6/7 confounders with evidence

Tier: deep-scored (abstract-extracted) · 8 supporting references. See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum, plasma or urine

Collection tube

Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container

Method / principle

LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available

Reagent / substrate

Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent

Platform

LC-MS/MS; some automated chemistry

Turnaround · availability

Send-out / research · Specialized / research