xanthosine
metaboliteXanthosine alleviates myocardial ischemia-reperfusion injury and ferroptosis, protecting cardiomyocytes through energy metabolism restoration.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleProtects cardiomyocytes from ischemia-reperfusion injury and ferroptosis via energy metabolism.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.Cellular & molecular biology letters · 2025 · PMID 40722060 · doi
- Exploring the mechanism underlying the cardioprotective effect of shexiang baoxin pill on acute myocardial infarction rats by comprehensive metabolomics.Journal of ethnopharmacology · 2020 · PMID 32464316 · doi