xanthurenic acid
metaboliteXanthurenic acid dysregulation reflects impaired tryptophan metabolism and systemic metabolic stress in acute MI.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleTryptophan metabolism intermediate; STEMI biomarker reflecting metabolic dysregulation.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research
Literature evidence(2)
- Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction.Scientific reports · 2024 · PMID 39394398 · doi
- Urinary metabonomic study of patients with acute coronary syndrome using UPLC-QTOF/MS.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2018 · PMID 30316136 · doi