ATP synthase subunit d
ATP5HgeneATP5H dysfunction triggers ferroptotic cardiomyocyte death during myocardial ischemia-reperfusion injury after coronary occlusion.
Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleFerroptosis-pathway marker; ischemia-reperfusion injury driver limiting cardiomyocyte survival post-infarction.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Single-cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia-reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024 · PMID 39520298 · doi