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Complement C1s serine protease
Pathway / Plaque inflammation

Complement C1s serine protease

C1Sgene

C1S genetic variants amplify complement-driven vascular inflammation increasing atherosclerotic instability risk.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleClassical complement; genetic involvement in atherosclerotic plaque instability.
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000182326

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
50
C — confounder / Type-II
66
A — assay feasibility
52
E — evidence strength
25
T1DI (composite)
6
Specificity differential (R−C)-15.8
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(2)