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Complement component C5
Pathway / Plaque inflammation

Complement component C5

C5protein

Complement-pathway effector generating C5a to recruit leukocytes and amplify thromboinflammatory response in acute coronary syndrome.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleComplement activation amplifies plaque inflammation and platelet recruitment; ACS biomarker and extreme LV dilation marker.
Also acts inPlatelet activation, Myocardial injury
Druggability
DruggableYes
Known drugs / candidates13
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000106804

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
60
A — assay feasibility
72
E — evidence strength
95
T1DI (composite)
19
Specificity differential (R−C)-45
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 2
2high-demand / peri-operative stressmag 2
3sudden cardiac deathmag 1
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedn/a
Coverage: 5/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 6 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(3)