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Procalcitonin
Pathway / Off-pathway / systemic markers

Procalcitonin

CALCApeptide

Procalcitonin is a systemic inflammatory marker elevated in MI-associated infection and ischemic stress, off the atherothrombotic cascade.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSystemic inflammatory biomarker; non-plaque-specific acute-phase response in MI.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000110680

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
96
E — evidence strength
49
T1DI (composite)
11
Specificity differential (R−C)-52
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 3
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 1
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 9 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Chemiluminescent sandwich immunoassay
Reagent / substrate
Anti-PCT antibody pair (BRAHMS)
Platform
Automated; POC
Turnaround · availability
Rapid · FDA-cleared

Literature evidence(3)