CELSR2

CELSR2gene

CELSR2 genetic variants regulate lipid retention and atherogenic lipoprotein handling, driving atherosclerotic lesion formation.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencemedium

RationaleCAD and MI susceptibility locus; likely involved in lipid metabolism and atherosclerosis initiation.

Also acts inVascular inflammation

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000143126

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

0.563

Open Targets association (myocardial_infarction)

GWAS associations

Traits: myocardial infarction