CO2

CO2gene

CO2 mitochondrial dysfunction elevates ROS production, promoting oxidative lipid modification and systemic inflammation in obesity-associated CAD.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencemedium

RationaleMitochondrial oxidative stress amplifies lipid oxidation and systemic inflammation; obesity association suggests metabolic link to CAD.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated

R — rupture / Type-I

—

C — non-Type-I

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-56.4

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

2sepsis / systemic inflammationmag 2

2anemia / acute blood lossn/a

2hypovolemia / dehydrationmag 2

2tachyarrhythmiamag 2

2hypoxemia / respiratory failuremag 3

2hypertensive emergencymag 2

2high-demand / peri-operative stressmag 2

3sudden cardiac deathmag 2

4aPCI-related periproceduraln/a

4bstent thrombosisn/a

4cin-stent restenosisn/a

5CABG-relatedn/a

Coverage: 7/12 axes with evidence

Tier: deep-scored (abstract-extracted) · 10 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Examining the Association between Mitochondrial Genome Variation and Coronary Artery Disease.
Genes · 2022 · PMID 35328073 · doi