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Cystatin C
Pathway / Off-pathway / systemic markers

Cystatin C

CST3protein

Cystatin C reflects glomerular filtration and renal function; elevated levels indicate cardiorenal risk and mortality in acute coronary syndrome.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleRenal function and cardiorenal stress marker; prognostic indicator independent of atherothrombotic cascade.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000101439

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
67
A — assay feasibility
68
E — evidence strength
62
T1DI (composite)
16
Specificity differential (R−C)-24
Direct evidence: higher in Type II (D=-2)
T1MI: 1.07 mg/L vs T2MI: 1.24 mg/L (p<0.05 after adjustment)
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Immunoturbidimetric/nephelometric
Reagent / substrate
Anti-cystatin C antibody-latex
Platform
Automated analyzer
Turnaround · availability
Routine · Widely available

Human genetic evidence

0.016
Open Targets association (STEMI)

Literature evidence(17)