FOXP3

FOXP3gene

FOXP3 hypermethylation impairs regulatory T cell function, promoting plaque inflammation and atherothrombotic progression.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleHypermethylation in CHD; FOXP3 regulates regulatory T cell differentiation and plaque inflammation.

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000049768

Type I vs Type II discrimination

ScoresIndeterminate

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+20

Confounder panel (Type-II drivers)

1sepsis / systemic inflammationmag 2

2anemia / acute blood lossn/a

3hypovolemia / dehydrationmag 0

4tachyarrhythmiamag 2

5hypoxemia / respiratory failuremag 1

6hypertensive emergencyn/a

7high-demand / peri-operative stressmag 2

Coverage: 5/7 confounders with evidence

Tier: deep-scored (abstract-extracted) · 14 supporting references. See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable