Pathway / Myocardial injury (shared endpoint)

Alpha-galactosidase

GLAgene

Alpha-galactosidase gene upregulation driving sphingolipid catabolism in ischemia-reperfusion injury.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencelow

RationaleEnzyme upregulation in I/R injury; sphingolipid catabolism during cardiomyocyte stress.

Druggability

DruggableYes

Known drugs / candidates2

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000102393

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated

R — rupture / Type-I

—

C — non-Type-I

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-51.7

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

2sepsis / systemic inflammationn/a

2anemia / acute blood lossmag 2

2hypovolemia / dehydrationn/a

2tachyarrhythmiamag 2

2hypoxemia / respiratory failuren/a

2hypertensive emergencyn/a

2high-demand / peri-operative stressn/a

3sudden cardiac deathn/a

4aPCI-related periproceduraln/a

4bstent thrombosisn/a

4cin-stent restenosisn/a

5CABG-relatedn/a

Coverage: 2/12 axes with evidence

Tier: deep-scored (abstract-extracted) · 3 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Spatial Metabolomics Reveals GLA-Mediated Imbalance of GalCer/GalCer as a Therapeutic Target in Myocardial Ischemia-Reperfusion Injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · PMID 41460520 · doi