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HIF1A
Pathway / Endothelial activation & erosion

HIF1A

HIF1Agene

HIF1A-driven endothelial-mesenchymal transition, mitochondrial dysfunction and reduced cardioprotective secretome promote endothelial erosion and myocardial injury.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleHypoxia-response transcription factor mediating endothelial dysfunction, erosion, and cardiomyocyte ischemic injury in MI.
Also acts inMyocardial injury, Cap degradation / rupture, Vascular inflammation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableNo
EnsemblENSG00000100644

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
78
A — assay feasibility
52
E — evidence strength
54
T1DI (composite)
5
Specificity differential (R−C)-63
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 3
2anemia / acute blood lossmag 3
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 18 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(5)