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N-terminal pro-A-type natriuretic peptide
Pathway / Off-pathway / systemic markers

N-terminal pro-A-type natriuretic peptide

NPPApeptide

MR-proANP reflects cardiac wall stress and hemodynamic burden following MI, prognosticating heart failure and mortality independent of coronary thrombosis.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleCardiac stress and hemodynamic marker; off atherothrombotic cascade.
Also acts inMyocardial injury
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000175206

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — confounder / Type-II
58
A — assay feasibility
66
E — evidence strength
21
T1DI (composite)
5
Specificity differential (R−C)-34.2
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Human genetic evidence

0.086
Open Targets association (acute_MI)

Literature evidence(8)