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B-type natriuretic peptide
Pathway / Off-pathway / systemic markers

B-type natriuretic peptide

NPPBprotein

BNP reflects post-infarction cardiac insufficiency and hemodynamic strain, operating off the atherothrombotic axis.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleAnchor molecule s0; cardiac remodeling and hemodynamic stress marker, not atherothrombotic cascade.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000120937

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
50
A — assay feasibility
96
E — evidence strength
67
T1DI (composite)
38
Specificity differential (R−C)+16.7
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 1
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 13 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Plasma (BNP: EDTA required); serum/plasma (NT-proBNP)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Chemiluminescent sandwich immunoassay
Reagent / substrate
Anti-BNP or anti-NT-proBNP antibody pair
Platform
Automated analyzer; POC (Alere Triage)
Turnaround · availability
STAT (~15–30 min) · FDA-cleared

Human genetic evidence

0.026
Open Targets association (STEMI)

Literature evidence(60)

Showing 40 of 60 linked references.

Clinical trials(1)