Solute Carrier Family 22 Member 3
SLC22A3geneA genetic susceptibility locus associated with MI risk, with pleiotropic or renal/metabolic effects.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleMI susceptibility locus; mechanism unclear, likely systemic.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000146477
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.252
Open Targets association (acute_MI)
3
GWAS associations
Traits: myocardial infarction
Literature evidence(1)
- Shared Genetic Liability Between Heart Failure and Myocardial Infarction Revealed by Genome-Wide Cross-Trait Analysis.Journal of cardiovascular pharmacology and therapeutics · 2026 · PMID 42141940 · doi