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Cardiac troponin
Pathway / Myocardial injury (shared endpoint)

Cardiac troponin

protein

Cardiac troponin is released from damaged cardiomyocytes upon ischemic necrosis, serving as the diagnostic standard for myocardial infarction.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleAnchor for myocardial necrosis; defines MI diagnosis.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
100
C — confounder / Type-II
61
A — assay feasibility
96
E — evidence strength
65
T1DI (composite)
43
Specificity differential (R−C)+38.9
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 1
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 23 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
High-sensitivity chemiluminescent/ECL sandwich immunoassay
Reagent / substrate
Paired anti-cTnI monoclonal antibodies (capture+detection), acridinium/ruthenium label
Platform
Automated core-lab analyzer (Abbott Architect/Alinity, Siemens Atellica, Roche cobas); Abbott i-STAT POC
Turnaround · availability
STAT (~15–60 min) · FDA-cleared, universal

Literature evidence(4)

Clinical trials(7)