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Chenodeoxycholic acid
Pathway / Off-pathway / systemic markers

Chenodeoxycholic acid

metabolite

Bile acid dysregulation associated with acute coronary syndrome, acting as a systemic metabolic marker rather than a direct atherothrombotic mechanism.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleBile acid metabolism marker; systemic metabolic axis independent of atherothrombotic cascade.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
28
C — confounder / Type-II
58
A — assay feasibility
42
E — evidence strength
22
T1DI (composite)
3
Specificity differential (R−C)-29.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum, plasma or urine
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top) · Sterile urine container
Method / principle
LC-MS/MS (targeted metabolomics) or enzymatic colorimetric where available
Reagent / substrate
Stable-isotope-labeled internal standard (MS); or enzyme-coupled Trinder reagent
Platform
LC-MS/MS; some automated chemistry
Turnaround · availability
Send-out / research · Specialized / research

Literature evidence(2)