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lactate dehydrogenase
Pathway / Myocardial injury (shared endpoint)

lactate dehydrogenase

protein

LDH is released from ischemic and necrotic myocardium during acute infarction, indicating cardiomyocyte death.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencehigh
RationaleMyocardial injury marker; released by necrotic cardiomyocytes; MI severity and mortality predictor.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
61
A — assay feasibility
96
E — evidence strength
25
T1DI (composite)
7
Specificity differential (R−C)-46.1
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressmag 1
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 11 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma (avoid hemolysis)
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Enzymatic kinetic (lactate→pyruvate, IFCC)
Reagent / substrate
L-lactate + NAD+ → pyruvate + NADH, read 340 nm
Platform
Automated chemistry analyzer
Turnaround · availability
Routine · Universal

Literature evidence(9)